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Neurological diseases are the foremost cause of disability and the second leading cause of death worldwide. Owing to the special microenvironment of neural tissues and biological characteristics of neural cells, a considerable number of neurological disorders are currently incurable. In the past few years, the development of nanoplatforms based on metal–organic frameworks (MOFs) has broadened opportunities...
Through inducing death receptor (DR) clustering to activate downstream signaling, tumor necrosis factor related apoptosis inducing ligand (TRAIL) trimers trigger apoptosis of tumor cells. However, the poor agonistic activity of current TRAIL‐based therapeutics limits their antitumor efficiency. The nanoscale spatial organization of TRAIL trimers at different interligand distances is still challenging,...
Photoelectric memristor has attracted many attentions thanks to their promising potential in optical communication chips and artificial vision systems. However, the implementation of an artificial visual system based on memristive devices remains a considerable challenge because most photoelectric memristors cannot recognize color. Herein, multi‐wavelength recognizable memristive devices based on...
The high reactivity of Li metal and the inhomogeneous Li deposition leads to the formation of Li dendrites and “dead” Li, which impedes the performance of Li metal batteries (LMBs) with high energy density. The regulating and guiding the Li dendrite nucleation is a desirable tactic to realize concentrated distribution of Li dendrites instead of completely inhibiting dendrite formation. Here, a Fe‐Co‐based...
Nanocomposites containing Ni or Co or NiCo alloy and nitrogen‐doped carbon with diverse ratios have been prepared and utilized as active elements in supercapacitors. The atomic contents of nitrogen, nickel, and cobalt have been adjusted by the supplement amount of Ni and Co salts. In virtue of the excellent surface groups and rich redox active sites, the NC/NiCo active materials exhibit superior electrochemical...
Solid Immersion Lens
In article number 2207596, Zushun Xu, Jing Zeng, Wen Fan, and co‐workers report a TiO2 nanoparticle‐assembled solid immersion lens (SIL) with excellent transparency, high refractive index and easy‐to‐handle size. This TiO2 SIL can provide a fast, wide‐field, real‐time, non‐destructive and low‐cost solution for improving the quality of optical microscopic observation of various...
Oncolytic Virotherapies
In article number 2206948, Ying Wu, Ning Li, Funan Liu, and co‐workers provide a more advanced approach to cancer immunotherapy, i.e. the oncolytic virotherapy. Oncolytic viruses selectively replicate in tumor cells and exert antitumor effects through direct oncolysis and inducting immune responses, where tumor antigens from the lysing cells enhance antitumor immunity.
Identifying and removing microplastics (MPs) from the environment is a global challenge. This study explores how the colloidal fraction of MPs assemble into distinct 2D patterns at aqueous interfaces of liquid crystal (LC) films with the goal of developing surface‐sensitive methods for identifying MPs. Polyethylene (PE) and polystyrene (PS) microparticles are measured to exhibit distinct aggregation...
The poor oxygen diffusion and sluggish oxygen reduction reaction (ORR) kinetics at multiphase interfaces in the cathode suppress the practical application of zinc‐air batteries. Developing effective strategies to tackle the issue is of great significance for overcoming the performance bottleneck but remains challenging. Here, a multiscale hydrophobic surface is designed on the iron single‐atom catalyst...
The widespread preexisting immunity against virus‐like particles (VLPs) seriously limits the applications of VLPs as vaccine vectors. Enabling technology for exogenous antigen display should not only ensure the assembly ability of VLPs and site‐specific modification, but also consider the effect of preexisting immunity on the behavior of VLPs in vivo. Here, combining genetic code expansion technique...
Scaling up the chemical vapor deposition (CVD) of monolayer transition metal dichalcogenides (TMDCs) is in high demand for practical applications. However, for CVD‐grown TMDCs on a large scale, there are many existing factors that result in their poor uniformity. In particular, gas flow, which usually leads to inhomogeneous distributions of precursor concentrations, has yet to be well controlled....
The high‐rate ethanol electrosynthesis from CO2 is challenging due to the low selectivity and poor activity, which requires the competition with other reduction products and H2. Here, the electrochemical reconstruction of Cs3Cu2Cl5 perovskite to form surface Cl‐bonded, low‐coordinated Cs modified Cu(200) nanocubes (CuClCs), is demonstrated. Density functional theory calculations reveal that the...
2D Fe‐chalcogenides have drawn significant attention due to their unique structural phases and distinct properties in exploring magnetism and superconductivity. However, it remains a significant challenge to synthesize 2D Fe‐chalcogenides with specific phases in a controllable manner since Fe‐chalcogenides have multiple phases. Herein, a molecular sieve‐assisted strategy is reported for synthesizing...
Recruitment of receptors at membrane interfaces is essential in biological recognition and uptake processes. The interactions that induce recruitment are typically weak at the level of individual interaction pairs, but are strong and selective at the level of recruited ensembles. Here, a model system is demonstrated, based on the supported lipid bilayer (SLB) that mimics the recruitment process induced...
Cancer immunotherapy is a promising antitumor approach, whereas nontherapeutic side effects, tumor microenvironment (TME) intricacy, and low tumor immunogenicity limit its therapeutic efficacy. In recent years, combination immunotherapy with other therapies has been proven to considerably increase antitumor efficacy. However, achieving codelivery of the drugs to the tumor site remains a major challenge...
Receptor Recruitment
Ligand‐functionalized lipid vesicles bind to receptor‐functionalized supported lipid bilayers through weak, multivalent receptor‐ligand interactions. As a result of binding, surface‐bound receptors move into the area of contact – a process called “recruitment” – to increase the local receptor density and thus enhance binding. The affinity, the size and the receptor density of...
Micro‐Supercapacitors
In article number 2207634, Hui Ying Yang and co‐workers develop an innovative stretchable micro‐supercapacitor with excellent resistance to freezing. Using digital light processing (DLP) 3D printing technology, an interdigital electrode with octet‐truss lattice structure has been designed to enhance the electrochemical performance of the micro‐supercapacitor. It is anticipated...
MXene‐Based Aptameric Fluorosensors
The aptamer‐functionalized MXene nanosheet acts as an effective bionanosensor for fluorescence‐enhanced detection of COVID‐19 with high sensitivity and specificity. This fluosensor is capable of detecting SARS‐CoV‐2 spike protein (limit of detection: 38.9 fg mL−1) and SARS‐CoV‐2 pseudovirus (limit of detection: 7.2 copies) within 30 min, and can also detect clinical...
Osteoarthritis (OA) is one of the most prevalent age‐related degenerative diseases. With an increasingly aging global population, greater numbers of OA patients are providing clear economic and societal burdens. Surgical and pharmacological treatments are the most common and conventional therapeutic strategies for OA, but often fall considerably short of desired or optimal outcomes. With the development...
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